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What Is ENBREL?

ENBREL is a prescription medicine that can be self-injected. It is used to treat five lifelong inflammatory diseases: moderate to severe rheumatoid arthritis (RA), moderate to severe plaque psoriasis, psoriatic arthritis, moderate to severe juvenile idiopathic arthritis (JIA), and ankylosing spondylitis (AS).


ENBREL is grouped within a class of medications called biologic response modifiers, or biologics. By working on the immune system, biologics block proteins that contribute to the disease process. Because ENBREL suppresses the immune system, patients are at a greater risk for getting serious infections.

 Enbrel is the number one most prescribed biologic by rheumatologists for RA. Enbrel is the number one most prescribed systemic therapy in dermatology for psoriatic diseases.

The science behind ENBREL

Tumor necrosis factor (TNF) is a substance made by your body's immune system. People with inflammatory diseases such as rheumatoid arthritis, plaque psoriasis, psoriatic arthritis, juvenile idiopathic arthritis, and ankylosing spondylitis have too much TNF in their bodies. ENBREL reduces levels of the active form of TNF.

The clinical history of ENBREL

  • Seventeen years of clinical experience
    • ENBREL has been studied for more than 17 years, and doctors have prescribed it for more than 10
  • ENBREL was the first biologic approved for moderate to severe rheumatoid arthritis
  • ENBREL has an established safety profile
  • ENBREL has over 10 years of continuous safety data in patients with rheumatoid arthritis

How ENBREL is taken

Taking ENBREL can be simple and convenient. ENBREL is injected (by you or a trained caregiver) just under the skin in the comfort of your own home. ENBREL is available in multiple injection options. And with the design of the Enbrel® (etanercept) SureClick® autoinjector, you'll never even have to see the needle. Schedule a training session with your doctor's office to learn the proper way to self-inject.

Click here to learn more about injecting ENBREL and to view step-by-step injection videos.

Injection site reactions such as redness, rash, swelling, itching, or bruising may occur. These symptoms usually go away within 3 to 5 days. If you experience these reactions and they don't go away or get worse, call your doctor.

If you ever have questions about injecting ENBREL, you can speak to a registered nurse at no cost to you. Just call 1-888-4ENBREL (1-888-436-2735) from 8 AM to 11 PM Eastern time, 7 days a week. This is just one of the many benefits of our ENBREL Support™ program.

Please see Full Prescribing Information, Important Safety Information, and Medication Guide for complete details about ENBREL.

Indications

Supportive data







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Based on monthly prescription data from IMS NPA for September 2009 and a 6-month interval of NDTI data for projected drug uses as of August 2009 for biologic agents approved for moderate to severe RA. Based on a 6-month interval of IMS NDTI prescription data for psoriatic disease as of October 2009 among systemic agents approved for psoriatic diseases. Prescription data for infusion products are not reported through IMS. Presentation of this information does not imply clinical efficacy.

Psoriatic disease comprises ICD-9 codes: psoriatic arthropathy and other psoriasis.

ENBREL is approved for chronic moderate to severe plaque psoriasis and psoriatic arthritis.

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