How ENBREL Works
Chronic inflammatory diseases like moderate to severe rheumatoid arthritis, ankylosing
spondylitis, and moderate to severe juvenile idiopathic arthritis are believed to be caused by a problem
with the immune system. The immune system protects the body from infections and certain diseases. One of the proteins that plays an important role in the immune system is called tumor necrosis factor (TNF).
Tumor necrosis factor (TNF)
People with these inflammatory conditions have too much TNF in their bodies. Although TNF is a normal part of immune response, increased levels of TNF play a role in the inflammation associated with certain rheumatic conditions. ENBREL reduces levels of the active form of TNF. ENBREL works on your immune system to reduce inflammation and help manage certain rheumatic conditions. ENBREL is not approved to treat all rheumatic conditions. ENBREL is indicated to treat rheumatic conditions like ankylosing spondylitis, psoriatic arthritis, and moderately to severely active RA and JIA.
Because ENBREL works on your immune system, it can lower the ability of your immune system to fight infections and may raise other safety concerns.
Please see Full Prescribing Information, Important Safety Information, and Medication Guide for complete details about ENBREL.